The Key Role of Splenectomy in Fever of unknown Origin which Resulted to be B-cell primary Splenic Lymphoma.

Background: The term ‘fever of unknown origin’ (FUO) was first introduced by Petersdorf and Beeson in 1961, it is defined as recurrent fever >38.3°C, lasting for >3 weeks, remaining undiagnosed after 1 week in-hospital evaluation. etiologies classic FUO include mainly infections, malignancies, non-infectious inflammatory diseases, miscellaneous causes, while some cases remain undiagnosed. Primary splenic lymphoma (PSL) a rare malignant lymphoma. In many cases, splenectomy the treatment choice massive splenomegaly.
 Case presentation: A 54-year-old woman presented with history high up to 39°C, sweating, fatigue, weight loss one month. She had been treated her family physician antibiotics (cephalosporin) 10 days but without improvement. On admission, patient palpable splenomegaly no lymphadenopathy. increased markers inflammation. indicators autoimmune disease were all negative. Screening specific infectious diseases blood cultures came out Abdominal computerized tomography (CT) revealed an enlarged spleen. performed spleen sent histological analysis. Meanwhile, subject complex treatment. Histological immunohistochemical analysis confirmed diagnosis diffuse large B-cell non-Hodgkin red pulp infiltration. Afterward, underwent systemic chemotherapy.
 Conclusion: We strongly suggest that clinicians should have index suspicion malignancies FUO. Sometimes can be key solving problem.